Dimethinden maleate
[CAS# 3614-69-5]

Identification

• Classification: API >> Antiallergic >> Antihistamine
• Name: Dimethinden maleate
• Synonyms: N,N-Dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine (2Z)-2-butenedioate; Dimethindene maleate; Dimethpyrindene maleate; Fenistil; Fenistil-retard; Fenostil; Forhistal maleate; NSC 107677; Su-6518
• Molecular Formula: C₂₀H₂₄N₂.C₄H₄O₄
• Molecular Weight: 408.50
• CAS Registry Number: 3614-69-5
• EC Number: 222-789-2
• SMILES: CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O

Properties

• Melting point: 159-161 °C

Safety Data

• Hazard Symbols: GHS07;GHS09 Warning
• Risk Statements: H302-H411
• Safety Statements: P264-P270-P273-P301+P317-P330-P391-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Acute toxicity	Acute Tox.	4	H302

Discovery and Applications

Dimethinden maleate, a potent antihistamine, was discovered through systematic exploration of chemical compounds. This discovery marked a significant advancement in pharmacology, providing a new therapeutic option for managing allergic symptoms such as itching, sneezing, and nasal congestion. Dimethinden maleate's efficacy in alleviating allergic reactions is attributed to its ability to antagonize histamine receptors, thereby blocking the action of histamine, a key mediator of allergic responses.

Dimethinden maleate is widely used for the symptomatic relief of allergic rhinitis, commonly known as hay fever. By blocking histamine receptors in the nasal mucosa, Dimethinden maleate reduces nasal congestion, sneezing, itching, and rhinorrhea. Dimethinden maleate is effective in the treatment of allergic conjunctivitis, an inflammatory condition of the eye caused by exposure to allergens such as pollen, dust, and pet dander. Its antihistamine properties alleviate ocular itching, redness, and swelling. Dimethinden maleate is indicated for the management of urticaria, a skin condition characterized by the sudden appearance of red, raised, and itchy welts or hives. By blocking histamine receptors in the skin, Dimethinden maleate reduces itching and inflammation associated with acute and chronic urticaria. Dimethinden maleate is used to alleviate itching and discomfort caused by insect bites and stings, including those from mosquitoes, bees, and ants. Its antihistamine properties help reduce histamine-induced inflammatory reactions at the site of the bite or sting.Dimethinden maleate-containing creams and ointments are employed in the management of dermatitis and eczema, inflammatory skin conditions characterized by itching, redness, and skin lesions. Dimethinden maleate is effective in relieving pruritus or itching associated with various dermatological conditions, including allergic reactions, insect bites, and contact dermatitis.

References

2003. Dimethindene. Pharmaceutical Substances.
URL: https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-04-0156