Ammonium acetate
[CAS# 631-61-8]

Identification

• Classification: Organic raw materials >> Carboxylic compounds and derivatives >> Salt of carboxylic acid ester and its derivatives
• Name: Ammonium acetate
• Synonyms: Acetic acid ammonium salt
• Molecular Formula: C₂H₇NO₂
• Molecular Weight: 77.08
• CAS Registry Number: 631-61-8
• EC Number: 211-162-9
• SMILES: CC(=O)[O-].[NH4+]

Properties

• Density: 1.07
• Melting point: 110-112 °C
• Flash point: 136 °C
• Water solubility: 1480 g/L (20 °C)

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H335
• Safety Statements: P261-P280-P305+P351+P338-P304+P340-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H302
Substances or mixtures corrosive to metals	Met. Corr.	1	H290
Eye irritation	Eye Irrit.	2A	H319

• Transport Information: UN 9079

Discovery and Applications

Ammonium acetate (NH4C2H3O2) has been known since the 18th century and was discovered by early chemical explorations into the reaction of acetic acid and ammonia. It is formed by the reaction of acetic acid with ammonium carbonate or ammonium hydroxide to give a white crystalline solid that is highly soluble in water to form solutions that can be used for a variety of practical purposes. Its chemical formula reflects its composition: one ammonium ion (NH4?) and one acetate ion (C2H3O2?).

In organic chemistry, ammonium acetate is an important reagent. It acts as a source of ammonia in the preparation of various compounds, reactions such as amide formation from acyl chlorides and amines. Its ability to decompose into acetic acid and ammonia when heated makes it useful in the synthesis of heterocyclic compounds and other complex organic molecules. This property has been exploited in research and industrial settings, supporting the development of pharmaceuticals, dyes, and agrochemicals.

Ammonium acetate plays an important role in pharmaceuticals. It is used in the formulation of drugs, particularly as a buffer to maintain pH stability. It ensures the proper delivery and effectiveness of the active ingredients in the drug, enhancing the therapeutic effect of the drug. It is also used as an electrolyte supplement in intravenous fluids, helping to maintain acid-base balance in patients with metabolic disorders.

In biochemical research, ammonium acetate is widely used in molecular biology protocols. It acts as a precipitant for nucleic acids, helping to purify and concentrate DNA and RNA in various extraction processes. Its ability to form neutral buffered solutions is very useful for electrophoresis and chromatography, which are essential techniques for analyzing and separating biomolecules. These applications support advances in genetics, biotechnology, and medical research.

In the textile industry, ammonium acetate is used as a mordant in the dyeing process, helping to fix the dye to the fabric and ensure color consistency. This application improves the durability and quality of dyed textiles. In addition, it is used as a food additive and acidity regulator in the food industry. Its ability to maintain pH and enhance flavor makes it suitable for a variety of foods, including sauces and baked goods.

Ammonium acetate can be used in industrial applications such as the production of foam rubber and as a catalyst for certain chemical reactions. Its role in environmental applications includes acting as a biodegradable deicer, providing an environmentally friendly alternative to traditional salt used to melt ice on roads and sidewalks. This reduces the impact of deicing activities on the environment.

Ammonium acetate is safe when used appropriately. Care should be taken to avoid ingestion of concentrated forms of ammonium acetate or contact with skin and eyes. Proper storage and handling practices ensure its safe use in laboratory and industrial settings, minimizing potential risks.

Ongoing research is exploring new applications for ammonium acetate and improving its production efficiency. Innovations in green chemistry and sustainable practices will expand its role in environmental solutions and advanced materials science, supporting efforts to address global challenges.

References

1971. Kinetics of synthesis of nitrogenase in batch and continuous culture of Anabaena flos-aquae. Archiv für Mikrobiologie.
DOI: 5002352

1979. Synthesis of phosphatidyl-dCMP in permeabilized normal human lymphocytes. Molecular and Cellular Biochemistry.
DOI: 460175